Peaceful, lawful protest - if it is effective - is innately disruptive of 'business as usual.' That is why it is effective.
The First Amendment was designed to allow for disruption of business as usual. It is not a quiet and subdued amendment or right.
Madonna is that forbidden thing, the Nietzschean creative woman. Her preoccupation with a high level of work doesn't allow her to follow the usual script that powerful women are expected to follow - 'don't hate me for my success, don't hate me for my power.'