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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
age way young
I am not old, but my young way was never the way to age. Charles Dickens
age church body
We devote the activity of our youth to revelry and the decrepitude of our old age to repentance: and we finish the farce by bequeathing our dead bodies to the chancel, which when living, we interdicted from the church. Charles Caleb Colton
age waste excess
The excesses of our youth are drafts upon our old age. Charles Caleb Colton
age matter fairytale
In a utilitarian age, of all other times, it is a matter of grave importance that fairy tales should be respected. Charles Dickens
age pay time-is-money
I've reached an age at which I'd rather pay more for something that "just works" than roll up my sleeves, reach for a spanner, and make it work. Time is money, and the older we get the less of it we've got left. Charles Stross
age amusement serious
Pleasure, so called, is the murderer of serious thought. This is the age of excessive amusement. Everybody craves for it, like a babe for its rattle! Charles Spurgeon
agents very-good turns
I knew with Snape I was working as a double agent, as it turns out, and a very good one at that. Alan Rickman
age towns my-family
Hee Haw was probably my biggest exposure to live music at a young age, because there wasn't any live music around my town and no one in my family played instruments. Alan Jackson
age golden golden-rule
Here's my Golden Rule for a tarnished age: Be fair with others, but keep after them until they're fair with you. Alan Alda
aged everybody files gang joe past
We've all aged some, but I just did, this past summer, another Rockford Files movie with the whole gang out there, Joe Santos and everybody else. Tom Atkins
aged bearable became emotional pain took
When we were young pain made us cry, but as we aged pain became bearable but the emotional pain took over. Aleksandr Sebryakov
aged died found injured man moments people sadly sharp
When we arrived, we found two people that were injured by sharp weapons. One of them was a man aged 20 who sadly died moments later. Olivier Lapointe
aged attention brains cognitive despite found functions men processing smaller speed
We found that, on average, men aged 64 years have smaller brains than men aged 60. However, despite this shrinkage, cognitive functions -- like memory, attention and speed of processing -- are unaffected. Helen Christensen
aged bent cancer care causes children fabulous five home indeed life loving requisite tasteful
Anya Hindmarch is indeed a handbag designer; she has the requisite fabulous life, tasteful home, and loving husband. She is also beautiful and self-deprecating, and has five children aged 5 to 20 and a philanthropic bent which spans causes from cancer care to Britain's Conservative Party. Kate Reardon
aged couple depth dogs experience home melts might realize tension weeks wise younger
Old dogs are the wise ones. There?s a depth, a feeling, like aged wine, you don?t get the same depth and experience with younger dogs. It might take a couple of weeks before they get used to the house, but you can see when they realize they are home - the tension melts away. Anne Solli
aged bit consistent focus ford improving model since vehicles year
Since the 1997 model year, Ford vehicles have been improving on a consistent basis. This year is a bit of an exception. The Focus is one of those vehicles that hasn't aged gracefully. Joe Ivers
aged cared created disabled elderly family home member nursing opposed passport people prefer provides reason services state supporting
Most of us would prefer that our own aged and infirm family member be cared for at home with the right kind of supporting services, as opposed to in a nursing home. For that reason the state created the PASSPORT program, which provides services to elderly and disabled people in their own homes. Bob Taft
aged behavior children patterns rate striking talking younger
We are talking about patterns of behavior. What is striking about this is that it suggests that the rate (of disorders) in these much younger children, aged 2-5, are not very different from what they will be in children of 9 or 14. Adrian Angold
almost fully investors money rate recommend simply since work
I almost always recommend investors get fully invested, since it's better to put your money to work than to let it simply track the rate of inflation. Louis Navellier
almost badly people provided schooling
The majority of people in Angola were not provided with any kind of schooling and were completely illiterate, very badly paid, and treated almost as slaves. Louis Leakey
almost begging ceremony good people private putting script
As a teenager, in my songbook, I used to script what my lighting would be like. I used to dance in my roo;, it was like putting myself in a trance, and making myself feel good about things, almost like a private ceremony of begging people to like you. Mika
almost body goes hip hurdles knee leg move split tells trainer
I hate leg exercises. I hate one-legged squats. I hate the hurdles and the split squats. I hate all the leg exercises. I know they help me, and I'm able to move around and don't have knee problems, and my hip doesn't hurt anymore, but when my trainer tells me I have to do them, I almost feel like my body goes into convulsions. Michael Strahan
almost along broken gets good hard pushed unless writer written
Nothing good gets written without the writer suffering along the way, in my opinion. Writing should be a pleasure, but unless you feel almost broken many, many times in the journey to a novel, you haven't pushed yourself hard enough. Mohsin Hamid
almost apologetic avoiding bars based brutal change exposed films flow money people suit truth
After 'Chandni Bar' there was a shutdown of such bars in Mumbai. After 'Page 3' people started avoiding such events. 'Traffic Signal' exposed the money flow through the mafia. I'm not apologetic about the brutal truth in my films. Almost 70% of my films are based on reality, and 30% I fictionalize or change to suit my film. Madhur Bhandarkar
almost fat great percentage product
The percentage of fat in this product here is almost 50 percent fat. But it's turkey. But because it's turkey, we think we're doing a great job. Margo Rodriguez
almost extremely following line sad
We are pretty much approaching the line of an almost Serb-free Kosovo, which is an extremely sad phenomenon. One exodus is following another. Kris Janowski
almost exception few odds people talked
We've already talked to people and it's completely safe, ... And with the exception of a few odds and ends, we're almost done. Chuck D.
blaming feeling himself normal sitting sorry watch
When you watch all these other projects, you always see the little guy, sitting in the corner, feeling sorry for himself and blaming the whole world, ... You don't see a normal person. Marc Singer
blaming grown stay
We're not blaming nothing on nobody. We're grown men. We've just got to find a way to stay on the floor. Fred Jones
blaming breed call care convinced culture entertainment fear genre older people rap recording report revenge stuff themselves turn violence younger youth
Most people who call and report stuff are older, ... Even when younger people turn themselves in, it's an older person who convinced them to do so. There's so much violence in youth culture, so much fear ? 'What if I get shot, if they find out?' Revenge is rare, but you see it more with the new breed of young thug-life characters. There's a whole genre of rap that promotes it. I'm not blaming the recording and entertainment industry, but it's that culture ? I'm hard, callous, I don't care . Alonzo Washington
blaming custody dad kids returned saying taken yelling
She started yelling and screaming. She didn't want to go. My dad returned her to custody up here (in the jail), but she was blaming me, saying her kids were going to be taken away from her. Heather Bishop
blaming
It's not blaming the victim. It's not anybody's fault. They just did something that didn't work, that's all. Kary Mullis
blaming deal juicy life selling
When we are out there selling a new picture, when did it become part of the deal that you have to sell the family? To use the juicy part of your life to get attention? I'm not blaming the reporters. It's the system. Jimmy Smits
blaming countries hard involved livestock proving shut
We are not blaming the countries involved who are doing all they can. But it is proving very hard to shut down markets, to slaughter chickens. Livestock is many people's livelihood. It is very worrying. Joseph Domenech
blaming certainly energy enthusiasm fast level played seen throughout year
I don't think we played very well. We didn't look quick, we didn't look fast and we didn't play with the same energy level that I've seen us play with throughout the year so far. I'm not blaming it on anything because that's not my nature, but we certainly didn't have the energy and the enthusiasm that we've played with to this point. Nick Saban
blaming deeply forms people tends though towards wider
I find it significant that, even though contemporary philosophy tends towards forms of determinism, in the wider culture people are deeply into naming, shaming and blaming each other. So we haven't lost that sense of conscience. John Cornwell
blogging days opening people preview public regard sure tweeting
I am sure if you went back to the days of 'My Fair Lady,' they would have had one public dress rehearsal, and that is it. And in a way, I would like to go back to that. Now you have people tweeting and blogging immediately, so you may as well regard your first preview as your opening night because you are going to get reviews. Tim Rice
blogging authenticity currency
The currency of blogging is authenticity and trust. Jason Calacanis
blogging built consumers days emerging ensure free genuine internet landscape open players point potential tv video
From our point of view, the important thing is that the emerging Internet TV landscape still has the potential to be free, non-commercial, and built on open standards, ... We're working to ensure that Internet TV is open and accessible, just like blogging and podcasting are. The days of proprietary video players are waning, as long as there are genuine alternatives for consumers that are free and open source. David Moore
blogging brian williams
I don't know why Brian Williams isn't blogging right now, Jeff Zucker
blogging
Blogging got the concept of personal publishing, but it didn't really take advantage of the network. Evan Williams
blogging twitter work
Blogging and traditional media work together. Twitter complements traditional media. Evan Williams
blogging fool stuff
Don't fool yourself that you're blogging when you're really just putting stuff up online. Andrew Sullivan
blogging clear crowd effective ignoring useful
Habits like blogging often and regularly, writing down the way you think, being clear about what you think are effective tactics, ignoring the burbling crowd and not eating bacon. All of these are useful habits. Seth Godin
blogging force overall positive
The influence of blogging is overall a very positive force in the media. Garrett Graff
exhausted remember
When youve exhausted all possibilities, remember thisyou havent. Robert H. Schuller
exhausted players stress throwing waking
We're mentally, physically, and emotionally exhausted right now. The stress -- we had players waking up and throwing up. Angela Ruggiero
exhausted
Lukashenko has exhausted the possibility of strengthening his power. Alexander Milinkevich
exhausted sometimes feels
Sometimes I get too exhausted to even feel bad Charles Bukowski
exhausted realizing pleasure
What we are only now beginning to fully realize is that in seeking material pleasure too constantly, the capacity for enjoyment or fulfillment decreases and eventually becomes exhausted. Alex Campbell
exhausted natural taxes-and-taxation
Of all our natural resources, the first one to be exhausted may be the taxpayer. Source Unknown
exhausted nobody sleeping success tells time transient
Nobody tells you when success comes around; in its transient way, you're just working and exhausted all the time. Sometimes I think I'm just sleeping in the back of cars, d'you know what I mean? James Corden
exhausted happen supposed
I exhausted everything, ... If it was supposed to happen it would have happened. It just was not supposed to and I'm comfortable with that. Allan Houston
exhausted sleeping swim
If they swim slow, we are where we need to be. Right now they should be exhausted and sleeping more than anything else. Francie Renfro
hard-times roots facts
Facts alone are wanted in life. Plant nothing else, and root out everything else. Charles Dickens
hard-times facts want
Now, what I want is, Facts. . . . Facts alone are wanted in life. Charles Dickens
hard-work easy-work problem
Dealing with failure is easy: Work hard to improve. Success is also easy to handle: You've solved the wrong problem. Work hard to improve. Alan Perlis
hard-work jealous thinking
I have no problem with the people who work hard to get success. But I think people are very jealous about success. I work very hard and they don't appreciate that. Alain Prost
hard-work acting joyful
Acting is hard work. At times, it's very energizing and enervating. It's childish. It's also responsible. It's illuminating, enriching, joyful, drab. It's bizarre, diabolical. It's exciting. Al Pacino
hard-work actors today
I'm glad that I'm being acclaimed as an actor. Today, when my hard work has paid off I can chill out about it. Akshay Kumar
hard-work mind lasts
The title always comes last. What I really work hard on is the beginning. Where do you begin? In what tone do you begin? I almost have to have a scene in my mind. David McCullough
hard-work mean pursuit-of-happiness
When the founders wrote about life, liberty, and the pursuit of happiness, they didn't mean longer vacations and more comfortable hammocks. They meant the pursuit of learning. The pursuit of improvement and excellence. In hard work is happiness. David McCullough
hard-work thinking focus
Hail, Caesar! is about, in my opinion - I love that movie - but I think it's about the idea that as glamorous as the business is, and for as much hoopla that surrounds moviemaking, ultimately it's just a job. If you focus on it, you can do it really well, and it takes a lot of hard work. David Krumholtz
sincere substitutes ardent
There is no substitute for thoroughgoing, ardent, and sincere earnestness. Charles Dickens
since stimulated
We started giving presentations at practitioner conferences in 1986, and since then all of our derivatives research has been stimulated by contact with practitioners. John Hull
sincere loses
How can we lose when we're so sincere? Charles M. Schulz
since
I've always been interested in singing, and I've always been singing and dancing since I was little. Lindsay Lohan
since
What they have done is insufficient. It's now two years since the decision. Jonathan Todd
since uncharted
We're in uncharted territory. We haven't experienced something like this since the 1980's. John Felmy
since
You know, I didn't get to go to university because I've been acting since I was a kid. Isla Fisher
since time
I say to my mother all the time, 'You're the child.' And she says, 'Yeah, you're the mother.' I've been that way with her since I was 11. Kristy McNichol
since
Since I can't write the greatest American novel, I'm going to write the longest American novel. Thomas Steinbeck
whose
I remember certain lines and whose they are. Warren Zevon
whose withhold
When you seek advice, do not withhold any facts from the person whose advice you seek. Abu Bakr