I feel like there is something about having a copacetic world POV that helps in making a comedy. Like, David Wain has such a particular way of looking at the world. It helps when everyone can see behind his eyes, you know?
While I've written in the POV (point of view) of adolescent characters before... I never have had to create novels in which those characters not only drive the plot, but also are instrumental in resolving whatever issue the plot deals with.