David Perlmutter Quotations

As a practicing neurologist, I can tell you first hand that working with Parkinson's patients offers clinical challenges. But from an emotional perspective, this disease can border on overwhelming.

Two forms of fat that are vitally important for brain health are cholesterol and saturated fat.

The science supporting the relationship between carbohydrates and dementia is quite exciting, as it paves the way for lifestyle changes that can profoundly affect a persons chances of remaining intact, at least from a brain perspective.

Increase your consumption of healthful fats like extra virgin olive oil, avocado, grass-fed beef, wild fish, coconut oil, nuts and seeds. At the same time, keep in mind that modified fats like hydrogenated or trans fats are the worst choices for brain health.

Bad things happen. And the human brain is especially adept at making sure that we keep track of these events. This is an adaptive mechanism important for survival.

The food we eat goes beyond its macronutrients of carbohydrates, fat and protein. It's information. It interacts with and instructs our genome with every mouthful, changing genetic expression.

While the hippocampus itself doesn't store memories, it serves to triage our experiences based upon their survival significance.

The human brain is at particularly high risk for damage by free radicals because of its high degree of metabolism compared to other tissues, while lacking the levels of antioxidant protection found elsewhere in the body.

Dementia is our most-feared illness, more than heart disease or cancer.

In general, the public knowledge base and thus decision-making behaviors are far more influenced by advertisement than with current science.

Shoot for a total of no more than 80 grams of carbs in your daily diet. This means favoring vegetables that grow above ground like kale, broccoli, spinach, and cauliflower as opposed to those that store carbohydrate in the form of starch like potatoes and beets.

It may seem draconian, but the best recommendation I can make is to completely avoid grains.

This low-fat idea that's been drummed into our heads and bellies is completely off-base and deeply responsible for most of our modern ills.

Throughout our lifetimes, we are constantly regenerating new brain cells in the hippocampus, a process called neurogenesis. New stem cells are constantly being born in the hippocampus that ultimately differentiate into fully functional neurons.

Even slight elevations in blood sugar have been shown to increase the risk of Alzheimer's disease.

When a child is watching television, he or she is not involved in play, not socializing with other individuals, and most importantly, not receiving feedback as to the actions or consequences of his or her behavior.

Humans are not the fastest or the strongest animals on the planet, but when it comes to survival, we have had the unique advantage of being clever.

Food is medicine. We can actually change our gene expressions with the foods we eat.

Parkinson's is described as a progressive idiopathic neurodegenerative disorder, a brain disease that will worsen with time for which no cause has as yet been identified.

Children need to be exploring their physical world. They need to be learning the fundamental laws of physics by manipulating objects.

From the earliest moments of life, children begin to learn the fundamentals of language. The most powerful influence for effective language development are the verbal interactions with caregivers.

Alzheimer's is a disease for which there is no effective treatment whatsoever. To be clear, there is no pharmaceutical agent, no magic pill that a doctor can prescribe that will have any significant effect on the progressive downhill course of this disease.

Rarely, Type 2 diabetes develops without any readily identifiable predisposing factor. But in the great majority of cases, it is brought on by lifestyle activities, including, and clearly most importantly, dietary choices.

The best diet for overall health, and specifically for heart, brain, and cancer risk reduction, is a diet that's aggressively low in carbohydrates with an abundance of healthful fat, and this is the central theme of 'Grain Brain.'

Fat is your friend. The brain thrives on a fat-rich, low-carbohydrate diet.

Inflammation is the cornerstone of Alzheimer's disease and Parkinson's, multiple sclerosis - all of the neurodegenerative diseases are really predicated on inflammation.

When we are exposed to a real or perceived threatening situation, powerful things happen in the brain to memorialize aspects of the event, including all manner of associated circumstances like where, when and how it occurred.

Making changes in the fast food that makes up such a significant part of the American diet, even if the numbers aren't impressive, will have important health up sides.

Mental fitness is served by consciously redirecting our attention away from the constant bombardment from the media whose reason to be seems to be focused on keeping us in a state of constant alert.

Memory enhancement self-help programs abound and promise improved memory performance by the utilization of any number of seemingly unique techniques focused on the context of how information is encoded.

Carbohydrates, whether derived from gluten-containing foods or other sources, including fruit, sweetened beverages, and starchy vegetables, are dangerous as they relate to brain health in and of themselves.

People are getting to this place of understanding that their lifestyle choices actually do matter a whole lot as opposed to this notion that you live your life, come what may, and hope for a pill.

Most grain foods, whether we're talking about quinoa, amaranth, the very popular grains of the day - the reality is they still are associated with a carbohydrate surge.

Eat your vegetables. Brush your teeth. Sweat once in a while. Get plenty of rest. Don't smoke. Laugh more. There are certain tenets to health that are pretty commonsensical and that we all know we should practice routinely.

Archives of Internal Medicine revealed that postmenopausal women who were put on statin drugs to lower their cholesterol had a nearly 48 percent increased risk of developing diabetes compared to those who weren’t given the drug.

We may all be sensitive to gluten from a neurological standpoint.

Strokes are categorized as either bleeding into the brain or a blockage in blood supply, known as an ischemic stroke. The latter are overwhelmingly more common, compromising about 87 percent of all stroke events.

Carbs are devastating for the brain.

The origin of brain disease is in many cases predominantly dietary. Although several factors play into the genesis and progression of brain disorders, to a large extent numerous neurological afflictions often reflect the mistake of consuming too many carbs and too few healthy fats.

Gluten is this Generation's Tobacco

Researchers have known for some time now that the cornerstone of all degenerative conditions, including brain disorders, is inflammation. But what they didn’t have documented until now are the instigators of that inflammation—the first missteps that prompt this deadly reaction. And what they are finding is that gluten, and a high-carbohydrate diet for that matter, are among the most prominent stimulators of inflammatory pathways that reach the brain.

We can change the expression of more than 70 percent of the genes that have a direct bearing on our health and longevity.

Far from being entirely dependent on exogenous food sources of antioxidants, our cells have their own innate ability to generate antioxidants upon demand.

The story of gluten as it relates to the brain throws a wide net, so much more encompassing than the inflammation of a small section of the small intestine that characterizes celiac disease.

Saturated fat is a fundamental building block for brain cells. It's certainly interesting to consider that one of the richest sources of saturated fat in nature is human breast milk.

Our ancestors relied upon their advanced brains to survive during times of food shortage, and fortunately, the human brain is able to utilize body fat as an extremely efficient fuel to sustain function when glucose-providing food is unavailable.

A fundamental premise in cancer therapy is trying to identify how the metabolism of cancer cells differs from normal tissue. When differences are identified, it often paves the way for treatments that will disrupt the cancer's metabolism while sparing normal tissue.

Antioxidants are chemicals that break down or neutralize the damaging effects of free radicals - chemicals produced as a byproduct of normal cellular metabolism.

As a practicing neurologist, I place central importance in applying current science to the notion of disease prevention.

The bottom line is that this author, a practicing neurologist dealing with Alzheimer's disease on a daily basis, believes we need to expand the public awareness that modifiable lifestyle factors have a profound role to play in determining who will or won't get this disease.

The biggest issue by far is that carbohydrates are absolutely at the cornerstone of all of our major degenerative conditions.

So-called 'complex carbs' may actually represent a more significant threat to health than simple sugar in that they may not only raise blood sugar, but keep it elevated for a more prolonged period of time.

The idea that people are nutritionally deprived because they don't eat grain has no scientific basis.

The Mediterranean diet is rich in fruits and vegetables while low in sodium. It is also enriched with olive oil, high in antioxidants as well as monounsaturated and polyunsaturated fats.