While these findings may be somewhat discouraging news for those wishing to reverse obesity through dietary interventions, they also highlight the importance of exercise.
Obesity is a very complex disease, and this metabolic pathway probably does not fully explain obesity, but we now know that SCD1 is at least a very important contributor.
Obesity is a very complex disease, and this metabolic pathway does not fully explain obesity, but it is a likely contributor.
We found that obesity was associated with a threefold increase in SCD1 expression in obese muscle, as well as a threefold higher level of SCD1 enzyme, compared to lean muscle.