In science fiction, basic doubts featured prominently in the worlds of Philip K. Dick. I knew Phil for 25 years, and he was always getting onto me, a scientist. He was a great fan of quantum uncertainty, epistemology in science, the lot.
The personal was, compared with the tides of great nations, a bothersome detail.
Because I've been a full professor doing research and lecturing at the University of California, I didn't have a lot of time to write, so I have always used my unconscious a great deal to do the really heavy lifting.
We have a name for people who create universes - they're called gods. There is no greater hubris than to think that we could take the place of godlike implications.