There are wonderfully intrinsic moments when life makes sense, and doubts are banished as irrelevant in those moments. Of course, we can't stay in that state. We're not here to be blissed out all the time.
I happen to be a Christian. I was brought up and drenched in that. I am very orthodox in thinking that Jesus acted in his life the way God would have acted if God had assumed human form.
The goal of spiritual life is not altered states, but altered traits
The scientific method is nearly perfect for understanding the physical aspects of our life. But it is a radically limited viewfinder in its inability to offer values, morals and meanings that are at the center of our lives.