David Madden Matter Quotations

Based on past studies, we expected greater activation in the frontal and parietal regions in the older adults, especially when top-down attention was required. We also hypothesized that an age-related related decline in the white matter integrity in the frontal part of the brain would correlate with changes in gray matter activation.

It appears that age-related cognitive changes are the result of combined influences on the gray matter and the white matter.